Keyword Analysis & Research: ivabradine mechanism

nih.gov

https://www.ncbi.nlm.nih.gov/books/NBK507783/

WEBMay 16, 2023 · Mechanism of Action. Ivabradine blocks the channel responsible for the cardiac pacemaker current, I (f), which regulates … Published: 2023/05/16

Published: 2023/05/16

DA: 33 PA: 10 MOZ Rank: 42

nih.gov

https://pubmed.ncbi.nlm.nih.gov/29939560/

DA: 99 PA: 44 MOZ Rank: 44

wikipedia.org

https://en.wikipedia.org/wiki/Ivabradine

OverviewMechanism of actionMedical usesContraindicationsAdverse effectsClinical trialsSociety and cultureIvabradine acts on the If (f is for "funny", so called because it had unusual properties compared with other current systems known at the time of its discovery) ion current, which is highly expressed in the sinoatrial node. If is a mixed Na –K inward current activated by hyperpolarization and modulated by the autonomic nervous system. It is one of the most important ionic currents for regulating pacemaker activity in the sinoatrial (SA) node. Ivabradine selectively inhibits the pace… Trade names: Corlanor, Procoralan Formula: C₂₇H₃₆N₂O₅

Trade names: Corlanor, Procoralan

Formula: C₂₇H₃₆N₂O₅

DA: 69 PA: 39 MOZ Rank: 17

nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671466/

WEBMECHANISM OF ACTION. Ivabradine is a heart-rate-lowering agent that acts by selectively and specifically inhibiting the cardiac pacemaker current (I f), a mixed … Author: Sally Tse, Nissa Mazzola Publication: P T. 2015 Dec; 40(12): 810-814. Publish Year: 2015 Published: 2015/12

Author: Sally Tse, Nissa Mazzola

Publication: P T. 2015 Dec; 40(12): 810-814.

Publish Year: 2015

Published: 2015/12

DA: 9 PA: 80 MOZ Rank: 68

microsoft.com

https://go.microsoft.com/fwlink/?linkid=2100071&clcid=0x409

Common brand names: CorlanorOVERVIEWSIDE EFFECTSINTERACTIONSDOSAGECommon side effectsVitreous floaterHypertensionAtrial fibrillationBlurred visionBradycardia Vitreous floater Hypertension Atrial fibrillation Blurred vision Bradycardia Vitreous floater Hypertension Atrial fibrillation Blurred vision Bradycardia Ventricular premature beats Atrioventricular block Headache disorder Dizziness Slow/fast/irregular heartbeat Fainting Rash Itching/swelling Slow/fast/irregular heartbeat Fainting Rash Itching/swelling Severe dizziness Trouble breathing Dizziness or tiredness may occur. If either of these effects persists or worsens, tell your doctor or pharmacist promptly. Ivabradine may rarely cause vision changes such as brief increased brightness, or seeing halos or colored bright lights. Sudden changes in light brightness may set off this effect. If vision changes happen, they usually start within the first 2 months and may go away during treatment or after stopping this medication.

Vitreous floater

Hypertension

Atrial fibrillation

Blurred vision

Bradycardia

Ventricular premature beats

Atrioventricular block

Headache disorder

Dizziness

Slow/fast/irregular heartbeat

Fainting

Rash

Itching/swelling

Severe dizziness

Trouble breathing

Dizziness or tiredness may occur. If either of these effects persists or worsens, tell your doctor or pharmacist promptly.

Ivabradine may rarely cause vision changes such as brief increased brightness, or seeing halos or colored bright lights. Sudden changes in light brightness may set off this effect. If vision changes happen, they usually start within the first 2 months and may go away during treatment or after stopping this medication.

DA: 20 PA: 7 MOZ Rank: 30

wikipedia.org

https://en.wikipedia.org/wiki/Ivabradine

DA: 29 PA: 44 MOZ Rank: 94

drugbank.com

https://go.drugbank.com/drugs/DB09083

WEB432 rows · Mechanism of action. Ivabradine lowers heart rate by selectively …

DA: 80 PA: 27 MOZ Rank: 5

ahajournals.org

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.115.018094

WEBMay 24, 2016 · Normal HCN channels create the diastolic If current ( A ), whereas ivabradine (Iv) inhibits ion passage in a current-dependent manner ( B ), diminishing If and slowing diastolic depolarization (red) …

DA: 36 PA: 22 MOZ Rank: 80

jacc.org

https://www.jacc.org/doi/10.1016/j.jacc.2017.08.038

WEBIt selectively inhibits the funny current ( If) in sinoatrial nodal tissue, resulting in a decrease in the rate of diastolic depolarization and, consequently, the heart rate, a mechanism that is distinct from those of …

DA: 18 PA: 30 MOZ Rank: 99