pvrig | PVRIG is a novel natural killer cell immune checkpoint recepto

Keyword	CPC	PCC	Volume	Score	Length of keyword
pvrig	1.63	1	638	63	5

Keyword	CPC	PCC	Volume	Score
pvrig	1.58	0.7	4664	40
pvrig gsk	1.59	0.6	7636	51
pvrig tigit	0.89	0.1	2997	90
virgo	0.03	0.4	5626	6
pvrig antibody	0.7	0.3	1084	85
pvrig cd112r	0.85	0.2	8521	73
pvrig gene	0.65	0.8	2627	34
pvrig ensemble id	1.14	0.8	5289	33

Search Results related to pvrig on Search Engine

PVRIG is a novel natural killer cell immune checkpoint receptor in
nih.gov

https://pubmed.ncbi.nlm.nih.gov/33147937/

WEBDec 1, 2021 · Abstract. This study explored the novel immune checkpoint poliovirus receptor-related immunoglobulin domain-containing (PVRIG) in acute myeloid leukemia (AML). We showed that AML patient blasts consistently expressed the PVRIG ligand (poliovirus receptor-related 2, PVRL2). Furthermore, PVRIG blockade significantly …

DA: 34 PA: 74 MOZ Rank: 20

The CD112R/CD112 axis: a breakthrough in cancer immunotherapy
biomedcentral.com

https://jeccr.biomedcentral.com/articles/10.1186/s13046-021-02053-y

WEBSep 10, 2021 · An emerging co-inhibitory receptor, CD112R (also called PVRIG), is most commonly expressed on natural killer (NK) and T cells. It binds to its ligand (CD112 or PVRL2/nectin-2) and inhibits the strength with which T cells and NK cells respond to cancer.

DA: 46 PA: 48 MOZ Rank: 69

PVRIG Expression Is an Independent Prognostic Factor and a …
nih.gov

https://pubmed.ncbi.nlm.nih.gov/36672396/

WEBJan 10, 2023 · PVRIG Expression Is an Independent Prognostic Factor and a New Potential Target for Immunotherapy in Hepatocellular Carcinoma. Cancers (Basel). 2023 Jan 10;15 (2):447. doi: 10.3390/cancers15020447.

DA: 32 PA: 24 MOZ Rank: 42

Abstract 5527: A novel fully human anti-TIGIT and PVRIG …
aacrjournals.org

https://aacrjournals.org/cancerres/article/82/12_Supplement/5527/700583/Abstract-5527-A-novel-fully-human-anti-TIGIT-and

WEBJun 15, 2022 · PVRIG (PVR-related immunoglobulin domain containing), which is another coinhibitory receptor of the DNAM/TIGIT/CD96 nectin family, binds with high affinity to PVRL2 and suppresses T-cell function, and shows nonredundant inhibitory effects alongside the TIGIT/PVR/PVRL2 axis.

DA: 5 PA: 88 MOZ Rank: 51

Blockade of checkpoint receptor PVRIG unleashes anti-tumor …
biomedcentral.com

https://jhoonline.biomedcentral.com/articles/10.1186/s13045-021-01112-3

WEBJun 26, 2021 · We found that PVRIG was highly expressed on tumor-infiltrating NK cells with exhausted phenotype. Furthermore, either PVRIG deficiency, early blockade or late blockade of PVRIG slowed tumor growth and prolonged survival of tumor-bearing mice by inhibiting exhaustion of NK cells as well as CD8+ T cells.

DA: 3 PA: 66 MOZ Rank: 59

Discovery of COM701, a therapeutic antibody targeting the novel …
ascopubs.org

https://ascopubs.org/doi/10.1200/JCO.2017.35.15_suppl.3074

WEBMay 30, 2017 · Conclusions: We demonstrated that targeting PVRIG with COM701, a high affinity antagonistic Ab, increased human T cell function. We further showed that PVRIG was induced in the tumor microenvironment and that disruption of PVRIG/PVRL2 interaction resulted in reduced tumor growth in preclinical models.

DA: 64 PA: 80 MOZ Rank: 39

Blockade of checkpoint receptor PVRIG unleashes anti-tumor ... - PubMed
nih.gov

https://pubmed.ncbi.nlm.nih.gov/34174928/

WEBJun 26, 2021 · Results: We found that PVRIG was highly expressed on tumor-infiltrating NK cells with exhausted phenotype. Furthermore, either PVRIG deficiency, early blockade or late blockade of PVRIG slowed tumor growth and prolonged survival of tumor-bearing mice by inhibiting exhaustion of NK cells as well as CD8 + T cells.

DA: 94 PA: 53 MOZ Rank: 32

DNAM-1 and the TIGIT/PVRIG/TACTILE Axis: Novel Immune Checkpoints …
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628015/

WEBJun 23, 2019 · PVRIG is a recently identified inhibitory receptor that interacts with CD112 competing with DNAM-1. Blocking PVRIG interaction with CD112 with antibodies enhanced T cell stimulation . In humans, blockade of PVRIG and TIGIT has been shown to enhance trastuzumab-mediated NK cell response against breast cancer . Antibody dependent cell ...

DA: 37 PA: 11 MOZ Rank: 49

252 Novel DNAM-1 axis member, PVRIG, is potentially a …
bmj.com

https://jitc.bmj.com/content/9/Suppl_2/A272

WEB252 Novel DNAM-1 axis member, PVRIG, is potentially a dominant checkpoint involved in stem-like memory T cells – dendritic cell interaction | Journal for ImmunoTherapy of Cancer. Home. Archive. Volume 9, Issue Suppl 2. Email alerts. PDF.

DA: 47 PA: 60 MOZ Rank: 99

THE TIGIT PATHWAY PVRIG, a Novel Pathway Member
q4cdn.com

https://s26.q4cdn.com/977440944/files/doc_presentations/2021/06/TIGIT-Deep-Dive-Eran-Ophir-29-June-2021.pdf

WEBJun 29, 2021 · • PVRIG is a novel checkpoint in the DNAM-1 axis, co-expressed with PD-1 and TIGIT in Tscm and exhausted T cells but uniquely clusters with early memory differentiation/ stem-like genes • PVRIG blockade show synergistic activity with TIGIT and PD-1 blockade in pre-clinical studies

DA: 37 PA: 84 MOZ Rank: 38