Mapec.at - MAPEC Trial: Recommend at least one antihypertensive at ... - ClinCalc

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WEBMAPEC Trial: Recommend at least one antihypertensive at night to improve cardiovascular outcomes. Recommend taking at least one antihypertensive medication at night. This simple, cost-effective intervention was recently shown in the MAPEC trial to modestly reduce cardiovascular events and mortality.

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MAPEC Trial: Recommend at least one antihypertensive at ... - ClinCalc
clincalc.com

https://clincalc.com/blog/2013/07/mapec-trial-recommend-at-least-one-antihypertensive-at-night-to-improve-cardiovascular-outcomes/

WEBMAPEC Trial: Recommend at least one antihypertensive at night to improve cardiovascular outcomes. Recommend taking at least one antihypertensive medication at night. This simple, cost-effective intervention was recently shown in the MAPEC trial to modestly reduce cardiovascular events and mortality.

DA: 51 PA: 59 MOZ Rank: 67

Lowering Nighttime Blood Pressure With Bedtime Dosing of
ahajournals.org

https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.121.16501

WEBIn MAPEC, 2156 white hypertensive patients were randomized to taking 1 or more of their antihypertensive medications at bedtime versus taking them all upon awakening. 28 After a median of 5.6 years, the use of bedtime dosing of antihypertensive medication was associated with significantly fewer cardiovascular events (6.3% versus 17.3%) and ...

DA: 58 PA: 8 MOZ Rank: 50

Lowering Nighttime Blood Pressure With Bedtime Dosing of
ahajournals.org

https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.120.16500

WEBAug 11, 2021 · The MAPEC Study, conducted at a single tertiary hospital, was the first prospective, randomized, CVD end point trial designed to specifically test the hypothesis that bedtime hypertension treatment with conventional once-a-day medications better reduces CVD risk than upon-waking therapy. 29 Patients with hypertension (N=2156) …

DA: 44 PA: 5 MOZ Rank: 9

The effect of taking blood pressure lowering medication at
nature.com

https://www.nature.com/articles/s41371-020-00469-1

WEBJan 18, 2021 · Noticeably, night-time BP dosing substantially reduced sleep SBP with an MD of change from baseline of −5.20 (−6.29, −4.11) mmHg in MAPEC and −3.70 (−4.06, −3.34) mmHg in Hygia trial ...

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Cardiovascular outcomes in adults with hypertension with …
thelancet.com

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01786-X/fulltext

WEBOct 11, 2022 · A recent systematic review identified only two completed randomised studies that have compared cardiovascular outcomes with morning and bedtime dosing of antihypertensive medication in adults with hypertension: the MAPEC study and the subsequent larger study from the same research group, the Hygia Chronotherapy Trial.

DA: 79 PA: 26 MOZ Rank: 77

Randomized Crossover Trial of the Impact of Morning or Evening …
ahajournals.org

https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.11101

WEBAug 27, 2018 · In the MAPEC study (Monitorización Ambulatoria de la Presión arterial y Eventos Cardiovasculares), 5 bedtime dosing of at least 1 blood pressure-lowering agent compared with only morning dosing was associated with better blood pressure control, reduced prevalence of non-dipping patterns, and reduced morbidity and mortality from …

DA: 69 PA: 34 MOZ Rank: 93

Sleep-time ambulatory blood pressure as a novel therapeutic
nature.com

https://www.nature.com/articles/jhh20141

WEBFeb 6, 2014 · The recently completed prospective outcome MAPEC Study verifies therapeutic restoration of the normal sleep-time BP decline, a novel therapeutic goal most effectively achieved by ingestion of the...

DA: 78 PA: 82 MOZ Rank: 48

Bedtime hypertension chronotherapy best reduces cardiovascular …
nih.gov

https://pubmed.ncbi.nlm.nih.gov/32684008/

WEBBedtime hypertension chronotherapy best reduces cardiovascular disease risk as documented by MAPEC and Hygia Chronotherapy outcomes trials. Chronobiol Int2020 May;37 (5):731-738. doi: 10.1080/07420528.2020.1771354. Epub 2020 Jul 20. The purpose of this communication is to describe the unique features of the investigative protocols of …

DA: 92 PA: 91 MOZ Rank: 86

Influence of circadian time of hypertension treatment on ... - PubMed
nih.gov

https://pubmed.ncbi.nlm.nih.gov/20854139/

WEBThe prospective MAPEC study was specifically designed to test the hypothesis that bedtime chronotherapy with ≥1 hypertension medications exerts better BP control and CVD risk reduction than conventional therapy, i.e., all medications ingested in the morning.

DA: 1 PA: 75 MOZ Rank: 29

The Circadian Clock in the Kidney - PMC - National Center for
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797999/

WEBThe master pacemaker of the circadian clock is located in the suprachiasmatic nucleus (SCN) of the brain. This central clock is entrained by light signals transmitted from the retina through the retinohypothalamic tract. A core group of clock genes functions in a series of transcription-based feedback loops ( Figure 1 ).

DA: 2 PA: 21 MOZ Rank: 37

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