|asparaginase mechanism of action||1.54||0.4||4045||40|
|aml and asparaginase||1.54||0.4||5680||50|
|asparaginase mode of action||1.74||0.1||3292||68|
The anti-leukemic effect of asparaginase is due to the fact that lymphoblastic leukemia cells are unable to synthesize adequate amounts of L-asparagine (Asn) and, therefore, depend on extracellular sources.When was asparaginase used to treat lymphosarcoma?
HISTORY OF ASPARAGINASE TO TREAT PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA. The use of asparaginase to treat patients with ALL can be traced to the discovery by Kidd in 1953 that guinea pig serum regressed Gardner 6C3HED lymphosarcoma xenografts implanted subcutaneously in mice.Does asparaginase influence dexamethasone pharmacokinetics in acute lymphoblastic leukemia?
35. Yang L., Panetta J.C., Cai X., Yang W., Pei D., Cheng C., Kornegay N., Pui C.H., Relling M.V. Asparaginase may influence dexamethasone pharmacokinetics in acute lymphoblastic leukemia. J. Clin. Oncol.What is the survival rate for patients with all with asparaginase?
L-asparaginase is an integral component of treatment for patients with ALL and since its introduction into pediatric treatment protocols in the 1960s, survival rates in children have progressively risen to nearly 90%.