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What is the maximum daily dosage of asparaginase?

The maximum single dose should not exceed 2 mg. Asparaginase 6,000 international units/m2 intramuscularly on days 4, 7, 10, 13, 16, 19, 22, 25, and 28 of the treatment period. When a remission is obtained with either of the above regimens, appropriate maintenance therapy must be instituted.

How do you administer asparaginase and prednisone?

Asparaginase 1,000 international units/kg/day intravenously for ten successive days beginning on day 22 of the treatment period. Prednisone 40 mg/m2 per day orally in three divided doses for 28 days (the total daily dose should be to the nearest 2.5 mg), following which the dosage of prednisone should be discontinued gradually over a 14 day period.

What is the preferred route of administration for Peg asparaginase?

IV or IM injection - IV administration is the recommended route of administration for PEG asparaginase for the Atlantic Provinces pediatric populations unless otherwise specified by the treatment protocol being followed for each patient. Patients who have a hypersensitivity reaction to PEG asparaginase will then be treated with IM Erwinia.

What is asparaginase used for?

Guidelines for Asparaginase Administration Asparaginase is an antineoplastic agent used most effectively and commonly in pediatrics in the treatment of acute lymphocytic leukemia (ALL), lymphoblastic lymphoma, and acute myeloid leukemia (AML).

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