Keyword Analysis & Research: asparaginase iu

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Frequently Asked Questions

What is L asparaginase used to treat?

Asparaginase. As a medication, L-asparaginase is used to treat acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and non-Hodgkin's lymphoma. It is given by injection into a vein, muscle, or under the skin. A pegylated version is also available. In food manufacturing it is used to decrease acrylamide.

What is the normal range of asparaginase activity?

In order to target an asparaginase activity level of 100 IU/L, a loading dose of 800 IU/m2(induction) and 600 IU/m2(intensification) is advised. In conclusion, variability of PEGasparaginase activity levels can be explained by body surface area, the treatment phase and the occurrence of an infection.

What is the source of asparaginase?

Based on studies in the 1960s using bacteria to identify alternate sources of asparaginase,[12,13,14] clinically available asparaginase is derived from two sources, namely Escherichia coliand Erwinia chrysanthemi. Native enzyme and an enzyme derivatized by the addition of monomethoxypolyethylene glycol (pegylated) are derived from E. coli.

How is asparaginase administered?

Unlike most of other chemotherapy agents, asparaginase can be given as an intramuscular, subcutaneous, or intravenous injection without fear of tissue irritation.

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