Keyword Analysis & Research: asparaginase liver


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What are the adverse effects of asparaginase on liver?

Asparaginase is a chemotherapeutic agent that is commonly used in combination with other medications for the treatment of acute lymphoblastic leukemia. An adverse effect of asparaginase includes hepatotoxicity, which can lead to severe liver failure and death. Several reports have documented success …

What is the pathophysiology of asparaginase toxicity?

Asparaginase-induced hepatotoxicity: rapid development of cholestasis and hepatic steatosis Asparaginase is a common cause of antineoplastic-induced liver injury with jaundice, typically with short latency, marked steatosis, and prolonged jaundice, which can lead to delays in antileukemic therapy.

Can Levocarnitine ameliorate asparaginase-induced hepatotoxicity?

Asparaginase, an important treatment component for acute lymphoblastic leukemia (ALL), causes severe hepatotoxicity in some patients. Levocarnitine is a mitochondrial co-factor that can potentially ameliorate the mitochondrial toxicity of asparaginase.

What is asparaginase used to treat?

Furthermore, asparaginase is almost exclusively used in acute lymphoblastic leukemia (ALL), which is a very rare cancer in adults. Currently, the long-acting pegylated form (pegasparaginase) is the only Escherichia coli –derived asparaginase available in the United States.


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