Keyword Analysis & Research: asparaginase tdm

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Is asparaginase a myelosuppressant?

Administering multiple successive asparaginase doses to adults despite prior hepatotoxicity is important since dose omission and/or lower total asparaginase dosing may jeopardise outcomes.1–3 Asparaginase, a key drug in all paediatric regimens, is not myelosuppressive.

What is asparaginase used to treat?

Furthermore, asparaginase is almost exclusively used in acute lymphoblastic leukemia (ALL), which is a very rare cancer in adults. Currently, the long-acting pegylated form (pegasparaginase) is the only Escherichia coli –derived asparaginase available in the United States.

What is the toxicity profile of asparaginase?

The toxicity profile of asparaginase, summarized in Table 1, is unique and is not observed with other chemotherapy agents. Furthermore, asparaginase is almost exclusively used in ALL, which is a rare cancer in adults. Table 1. . . . . Toxicity . Any grade (%) . High grade (≥ 3) (%) . Risk factors . BMI, body mass index.

Should Universal premedication for asparaginase-based therapy be standard of care?

We propose universal premedication for PEG be standard of care. Universal premedication and therapeutic drug monitoring for asparaginase-based therapy prevents infusion-associated acute adverse events and drug substitutions Pediatr Blood Cancer. 2019 Aug;66(8):e27797.doi: 10.1002/pbc.27797.

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