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What is the function of PI3P?

Phosphatidylinositol‐3‐phosphate (PI3P) is a key player in membrane dynamics and trafficking regulation. Most PI3P is associated with endosomal membranes and with the autophagosome preassembly machinery, presumably at the endoplasmic reticulum.

Is PI3P a phosphoinositide?

Phosphatidylinositol‐3‐phosphate (PI3P) is a phosphoinositide [1]. Many lipids, including some phosphoinositides such as PI4,5P 2, have been shown to play crucial roles in cellular organization, motility and intracellular membrane trafficking [2] including membrane protrusion, invagination and remodelling.

Is there a PI3P pool at autophagosomes and preautophagosomal structures?

It had been assumed that a local PI3P pool was present at autophagosomes and preautophagosomal structures, such as the omegasome and the phagophore. This was recently confirmed by the demonstration that PI3P-binding proteins participate in the complex sequence of signalling that results in autophagosome assembly and activity.

Where is PI3P present in the cell membrane?

Finally, PI3P is observed at sites of LC3-associated phagocytosis and it was recently shown at the primary cilium and/or ciliary pocket (Fig. 1 ). Endomembrane trafficking and phosphoinositide subcellular localization.


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