Keyword Analysis & Research: mesp1


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What is the function of MESP1?

MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube The Mesp1 gene encodes the basic HLH protein MesP1 which is expressed in the mesodermal cell lineage during early gastrulation.

Is MESP1 a progenitor of the heart?

[…] Mesp1 directs multipotential cardiovascular cell fates, even though it’s transiently induced prior to the appearance of the cardiac progenitor program. Tracing Mesp1-expressing cells and their progeny allows isolation and characterization of the earliest cardiovascular progenitor cells.

What is the MESP1 subpopulation?

Thus, Mesp1 is a specified subpopulation out of the Flk1+/PDGFRa+ cells and BMP signaling is the most potent driver of the Mesp1-CPCs.

What diseases are associated with the MESP1 gene?

Diseases associated with MESP1 include Double Outlet Right Ventricle and Myasthenic Syndrome, Congenital, 12 . Among its related pathways are Cardiac Progenitor Differentiation . Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein dimerization activity .


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