Keyword Analysis & Research: pathophysiology of copd ncbi


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What is pathophysiology of COPD?

The pathophysiology of severe COPD exacerbations requiring mechanical ventilation is now well understood. Increased airways resistance, usually as a result of worsening airway inflammation, results in critical EFL and DH with dramatically increased loading and functional weakness of the inspiratory muscles.

What are the clinical manifestations of COPD?

Clinical Manifestations. The natural history of COPD is variable but is a generally progressive disease. Chronic cough. Chronic cough is one of the primary symptoms of COPD. Sputum production. There is a hyperstimulation of the goblet cells and the mucus-secreting gland leading to overproduction of sputum. Dyspnea on exertion. Dyspnea is usually progressive, persistent, and worsens with exercise.


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