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These observations led to the pharmacologically most relevant theory of depression, referred to as the monoamine-deficiency hypothesis. The monoamine-deficiency theory posits that the underlying pathophysiological basis of depression is a depletion of the neurotransmitters serotonin, norepinephrine or dopamine in the central nervous system.What kind of pathology causes depression?
Various genetic factors are responsible for the development of depression-induced AD. Current evidence shows molecular mechanisms and cascade involved in the pathology of depression such as chronic inflammation, HPA axis deregulation, and low-level neurotropic factors.What are the signs and symptoms of clinical depression?
Warning signs include: A sudden switch from sadness to extreme calmness, or appearing to be happy Clinical depression (deep sadness, loss of interest, trouble sleeping and eating) that gets worse Taking risks that could lead to death, such as driving through red lightsWhat are the physiological symptoms of depression?
Some of the most common physical symptoms of depression include: Chest Pain: Not very common, see your doctor to rule out other causes. Depression can also raise your risk of heart disease Fatigue and Exhaustion: Feeling too tired to complete everyday tasks, even if you’ve gotten eight hours of sleep.