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Depression involves an overemphasis of negative emotions and a decrease in the reward produced by pleasurable experiences. Chronic stress can be important in the development of depression. An inability to cope with stress causes changes in how the brain balances positive and negative information. Key structures include the prefrontal cortex ...What is the pathophysiology of major depressive disorder?
What is the pathophysiology of major depressive disorder? The underlying pathophysiology of major depressive disorder has not been clearly defined. Current evidence points to a complex interaction between neurotransmitter availability and receptor regulation and sensitivity underlying the affective symptoms.What are the symptoms of a depression?
There are some common symptoms of depression anyone can experience, which can include being withdrawn, losing interest in friends and activities you used to enjoy, and difficulty concentrating on things.  You feel down or irritated most of the day, nearly every day.What are the physical causes of depression?
There are some physical health problems that can cause depression: conditions affecting the brain and nervous system hormonal problems, especially thyroid and parathyroid problems symptoms relating to the menstrual cycle or the menopause low blood sugar sleep problems.