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Understanding depression pathophysiology is challenging because varying depression symptomatology cannot be explained by single hypothesis. Pathophysiologic mechanisms include: monoamine hypothesis, genetic, environmental, immunologic, endocrine factors and neurogenesis.What causes depression?
For some people, an upsetting or stressful life event, such as bereavement, divorce, illness, redundancy and job or money worries, can be the cause. Different causes can often combine to trigger depression. For example, you may feel low after being ill and then experience a traumatic event, such as a bereavement, which brings on depression.What are the symptoms of depression?
Symptoms of depression can include feeling low, bad about yourself and not wanting to do things. Depression can be caused by anything, but family history, upbringing, stressful events and your lifestyle can have an effect. Professionals describe depression as ‘mild’, ‘moderate’ or ‘severe’. Treatment will depend on how they describe it.What is the etiology of major depressive disorder (MDD)?
Children and adolescents with MDD may present with irritable mood. Per DSM-5, other types of depression falling under the category of depressive disorders are: The etiology of Major depressive disorder is believed to be multifactorial, including biological, genetic, environmental, and psychosocial factors.