Keyword Analysis & Research: pms2


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pms20.290.3659464

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pms21.25148356

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  • About Mutations in the PMS2 Gene - Memorial Sloan Kettering Cancer Center

    mskcc.org

    https://www.mskcc.org/cancer-care/patient-education/about-mutations-pms2-gene

    WEBJul 17, 2023 · Your PMS2 gene normally helps prevent cancers. A mutation in this gene causes it to stop working like it should. It is important to understand that having a mutation in this gene does not mean you will definitely develop cancer. It means that you have an increased risk of developing certain types of cancers.

    DA: 35 PA: 56 MOZ Rank: 73

  • The Changing Landscape of Lynch Syndrome due to PMS2 …

    nih.gov

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995637/

    WEBIn this review, we discuss the role of PMS2 in the MMR pathway, the evolving testing criteria used to identify variants in the PMS2 gene, the LS phenotype as well as the autosomal recessive condition called Constitutional Mismatch Repair Deficiency syndrome, and current methods used to elucidate the clinical impact of PMS2 mutations.

    DA: 48 PA: 88 MOZ Rank: 57

  • PMS2 - Wikipedia

    wikipedia.org

    https://en.wikipedia.org/wiki/PMS2

    WEBPMS2 is a protective mediator of cell survival in p53-deficient cells and modulates protective DNA damage response pathways independently of p53. PMS2 and MLH1 can protect cells from cell death by counteracting p73-mediated apoptosis in a …

    DA: 80 PA: 67 MOZ Rank: 63

  • Cancer Risks for PMS2 -Associated Lynch Syndrome

    ascopubs.org

    https://ascopubs.org/doi/10.1200/JCO.2018.78.4777

    WEBAug 30, 2018 · Heterozygous PMS2 mutation carriers were at small increased risk for colorectal and endometrial cancer but not for any other Lynch syndrome–associated cancer. This finding justifies that PMS2 -specific screening protocols could be restricted to …

    DA: 74 PA: 90 MOZ Rank: 30

  • PMS2-associated Lynch syndrome: Past, present and future

    nih.gov

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9989154/

    WEBFeb 21, 2023 · In this review we discuss the current knowledge, current (clinical) challenges and knowledge gaps that should be targeted by future studies. Keywords: Lynch syndrome (hereditary nonpolyposis colorectal cancer), mismatch repair (MMR), PMS2 gene, colorectal cancer, endometrial cancer, carcinonogenesis. Go to:

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  • PMS2 gene: MedlinePlus Genetics

    medlineplus.gov

    https://medlineplus.gov/genetics/gene/pms2/

    WEBThe PMS2 gene provides instructions for making a protein that plays an essential role in repairing DNA. This protein helps fix errors that are made when DNA is copied (DNA replication) in preparation for cell division. The PMS2 protein joins with another protein called MLH1 (produced from the MLH1 gene) to form a two-protein complex called a dimer.

    DA: 71 PA: 6 MOZ Rank: 73

  • Lynch Syndrome - GeneReviews® - NCBI Bookshelf

    nih.gov

    https://www.ncbi.nlm.nih.gov/books/NBK1211/

    WEBFeb 5, 2004 · The diagnosis of Lynch syndrome is established in a proband by identification on molecular genetic testing of a germline heterozygous pathogenic variant in MLH1, MSH2, MSH6, or PMS2 or of an EPCAM deletion. Management. Treatment of manifestations: Adenomas of colon: complete endoscopic polypectomy with follow-up colonoscopy …

    DA: 40 PA: 83 MOZ Rank: 63

  • PMS2 Gene - GeneCards | PMS2 Protein | PMS2 Antibody

    genecards.org

    https://www.genecards.org/cgi-bin/carddisp.pl?gene=PMS2

    WEBApr 3, 2024 · PMS2 (PMS1 Homolog 2, Mismatch Repair System Component) is a Protein Coding gene. Diseases associated with PMS2 include Lynch Syndrome 4 and Mismatch Repair Cancer Syndrome 4. Among its related pathways are DNA repair pathways, full network and Gene expression (Transcription).

    DA: 75 PA: 33 MOZ Rank: 43

  • LYNCH SYNDROME: IMPLICATIONS OF AN ALTERED …

    massgeneral.org

    https://www.massgeneral.org/assets/mgh/pdf/cancer-center/genetics/pms2/pms2_result_handout_2021.pdf

    WEBPMS2 is a type of tumor suppressor gene known as a DNA mismatch repair gene. When working correctly, tumor suppressor genes help to prevent cancer by controlling the growth and division of cells. • People born with a PMS2 pathogenic variant have only one working copy of the PMS2 gene, so their risk for cancer is higher than average.

    DA: 19 PA: 10 MOZ Rank: 14

  • Lynch syndrome, molecular mechanisms and variant …

    nature.com

    https://www.nature.com/articles/s41416-022-02059-z

    WEBNov 24, 2022 · Lynch syndrome (LS) is a hereditary cancer predisposition disease, caused by germline variants that impair the DNA mismatch repair (MMR) system and lead to the accumulation of spontaneously...

    DA: 71 PA: 39 MOZ Rank: 16