WEBJan 15, 2021 · Peer Reviewed. Introduction. QT interval prolongation is a common side effect shared among the most effective antiemetic classes. The risk of QT prolongation is exacerbated by electrolyte abnormalities observed in patients with ongoing emesis, particularly hypokalemia.
DA:79PA:90MOZ Rank:79
Antiemetic drugs: what to prescribe and when - PMC
WEBApr 1, 2020 · QT prolongation. The risk of prolonging the QT interval on the ECG is important to consider when prescribing antiemetic drugs. While the effect may not be significant in isolation, the risk of dysrhythmia increases with other risk factors affecting the QT interval, such as drugs, hypokalaemia and hypocalcaemia.
WEBAug 17, 2020 · Absence of QT prolongation (perhaps the greatest advantage). Longer half-life (~40 hours). Superior efficacy compared to ondansetron (especially the 8-mg dosing of ondansetron). 0.25 mg palonosetron IV is a commonly used dose for prevention of chemotherapy-induced nausea and vomiting.
DA:16PA:44MOZ Rank:29
Drugs to be avoided in patients with long QT syndrome: Focus on …
WEBApr 4, 2013 · Core tip: Long QT syndrome is a cardiac conduction disorder characterized by prolongation and increased dispersion of ventricular repolarization, manifested by lengthening of the QT interval on the surface electrocardiography. This review furnishes important key points for preoperative optimization, intraoperative anesthetic agents and ...
WEBJul 2, 2023 · It is generally accepted that QT prolongation past 500 ms carries an increased risk of torsades de pointes. The degree of QT prolongation is correlated to the level of risk, with severe prolongations being associated with much higher risk.
DA:56PA:100MOZ Rank:23
Acquired long QT syndrome: Clinical manifestations ... - UpToDate
WEBFeb 6, 2023 · Samuel Asirvatham, MD. Deputy Editor: Susan B Yeon, MD, JD. Literature review current through: Jan 2024. This topic last updated: Feb 06, 2023. INTRODUCTION. The long QT syndrome (LQTS) is a disorder of myocardial repolarization characterized by a prolonged QT interval on the electrocardiogram (ECG) ( waveform 1 ).
DA:26PA:54MOZ Rank:62
Mechanisms and management of drug-induced QT prolongation
WEBFirst published: 21 November 2022. https://doi.org/10.1002/psb.2023. Citations: 1. Sections. PDF. Tools. Share. Abstract. Many drugs are associated with QT prolongation and certain patient factors can increase this effect, leading to a significant risk of arrhythmias.
DA:27PA:95MOZ Rank:74
Clinical guidance for navigating the QTc-prolonging and
WEBAt the forefront is the potential to prolong the heart rate–corrected QT interval (QTc), thereby increasing the risk of drug-induced torsades de pointes (TdP) and resultant drug-induced sudden cardiac death (SCD).
DA:6PA:6MOZ Rank:14
When Should QT Prolongation Be Considered in Antiemetic …
WEBQTc prolongation from routine doses of 4–8 mg of ondansetron is minimal and is unlikely to be clini-cally significant or cause a dangerous arrhythmia. A patient who receives a single dose of an anti-emetic does not require routine screening electro-lytes or an electrocardiogram (ECG).
DA:97PA:66MOZ Rank:23
High-Throughput Assessment of Real-World Medication Effects on QT
