Kras.nl - KRAS - Wikipedia

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WebKRAS (Kirsten rat sarcoma virus) is a gene that provides instructions for making a protein called K-Ras, a part of the RAS/MAPK pathway. The protein relays signals from outside the cell to the cell's nucleus.

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KRAS - Wikipedia
wikipedia.org:443

https://en.m.wikipedia.org:443/wiki/Kras

WebKRAS (Kirsten rat sarcoma virus) is a gene that provides instructions for making a protein called K-Ras, a part of the RAS/MAPK pathway. The protein relays signals from outside the cell to the cell's nucleus.

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KRAS mutation: from undruggable to druggable in cancer
nature.com:443

https://www.nature.com:443/articles/s41392-021-00780-4

WebNov 15, 2021 · Kirsten rat sarcoma viral oncogene homologue (KRAS) is the best-known oncogene with the highest mutation rate among all cancers and is associated with a series of highly fatal cancers, including...

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KRAS gene: MedlinePlus Genetics
medlineplus.gov:443

https://medlineplus.gov:443/genetics/gene/kras/

WebThe KRAS gene provides instructions for making a protein called K-Ras that is part of a signaling pathway known as the RAS/MAPK pathway. Learn about this gene and related health conditions.

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The current understanding of KRAS protein structure and dynamics
nih.gov:443

https://www.ncbi.nlm.nih.gov:443/pmc/articles/PMC6965201/

WebDec 26, 2019 · GTPase KRas (KRAS) is a signal transducer protein, which plays an important role in various cellular signalling events such as in regulation of cell proliferation. It is a critical hub in the cell circuitry, as upon an upstream stimulus it transduces activating signals to several cellular signalling pathways, including the mitogen-activated ...

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Targeting the KRAS mutation for more effective cancer treatment
mdanderson.org:443

https://www.mdanderson.org:443/cancerwise/targeting-the-kras-mutation-for-more-effective-cancer-treatment.h00-159458478.html

WebFeb 12, 2021 · KRAS mutations are present in approximately 25% of tumors, making them one of the most common gene mutations linked to cancer. They are frequent drivers in lung, colorectal and pancreatic cancers. KRAS drives 32% of lung cancers, 40% of colorectal cancers, and 85% to 90% of pancreatic cancer cases.

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What’s new in KRAS mutation research? - MD Anderson Cancer …
mdanderson.org:443

https://www.mdanderson.org:443/cancerwise/what-s-new-in-kras-mutation-research-.h00-159696756.html

WebApril 04, 2024. What’s new in KRAS mutation research? BY Christina Sumners. Cancer cells often develop genetic mutations that initiate and sustain the growth of tumors. The most frequently mutated of these oncogenic driver genes, called KRAS, is associated with some of the most fatal cancer types: lung, pancreatic and colorectal cancers.

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Oncogenic KRAS: Signaling and Drug Resistance - PMC
nih.gov:443

https://www.ncbi.nlm.nih.gov:443/pmc/articles/PMC8616169/

WebNov 9, 2021 · KRAS is one of the oncogenic proteins and best well-known GTPase proteins. Although KRAS serves as regulation of cellular process, abnormal mutated and GTP-bound KRAS is highly expressed in human cancers. Understanding biological characteristics and precise signaling of KRAS proteins is essential for targeted cancer therapy.

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Sotorasib is First KRAS Inhibitor Approved by FDA - NCI
cancer.gov:443

https://www.cancer.gov:443/news-events/cancer-currents-blog/2021/fda-sotorasib-lung-cancer-kras

WebJun 25, 2021 · Doctors and scientists have known for decades that harmful mutations in a gene called KRAS are the root cause of cancer for hundreds of thousands of people. But there have been no effective treatments that counteract the cancer-fueling actions of mutant KRAS proteins —until now.

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A single inhibitor for all KRAS mutations | Nature Cancer
nature.com:443

https://www.nature.com:443/articles/s43018-023-00615-x

WebAug 24, 2023 · KRAS — the most commonly mutated oncogene — is altered in about 20% of all cancers, but was considered undruggable for more than 3 decades 1. KRAS is a member of the RAS family of...

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Role of oncogenic KRAS in the diagnosis, prognosis and ... - Nature
nature.com:443

https://www.nature.com:443/articles/s41575-019-0245-4

WebJan 31, 2020 · The oncogenic KRAS mutation is the major event in pancreatic cancer; it confers permanent activation of the KRAS protein, which acts as a molecular switch to activate various intracellular...

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IP	195.128.186.60
Domain infomation	Domain name: kras.nl Status: active Registrar: TUI Nederland N.V. Zuiderval 120 7543EZ Enschede Netherlands Abuse Contact: Creation Date: 1996-06-26 Updated Date: 2016-07-14 DNSSEC: no Domain nameservers: ns1.tui.nl ns2.tui.nl Record maintained by: SIDN BV Copyright notice No part of this publication may be reproduced, published, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, recording, or otherwise, without prior permission of SIDN. These restrictions apply equally to registrars, except in that reproductions and publications are permitted insofar as they are reasonable, necessary and solely in the context of the registration activities referred to in the General Terms and Conditions for .nl Registrars. Any use of this material for advertising, targeting commercial offers or similar activities is explicitly forbidden and liable to result in legal action. Anyone who is aware or suspects that such activities are taking place is asked to inform SIDN. (c) SIDN BV, Dutch Copyright Act, protection of authors' rights (Section 10, subsection 1, clause 1).