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DOI: 10.1016/j.bbr.2017.12.025 Abstract A number of factors (biogenic amine deficiency, genetic, environmental, immunologic, endocrine factors and neurogenesis) have been identified as mechanisms which provide unitary explanations for the pathophysiology of depression.What causes a major depressive episode?
However, events and stressors that cause demoralization and grief can also precipitate a major depressive episode Major depression (unipolar disorder) Depressive disorders are characterized by sadness severe enough or persistent enough to interfere with function and often by decreased interest or pleasure in activities.What is the diagnosis of major depressive disorder?
The diagnosis of depression is based on history and physical findings. No diagnostic laboratory tests are available to diagnose major depressive disorder. Laboratory studies are, however, useful to exclude medical illnesses that may present as major depressive disorder. These laboratory studies might include the following:Are laboratory findings pathognomonic for depressive disorders?
No laboratory findings are pathognomonic for depressive disorders. However, laboratory testing is necessary to exclude physical conditions that can cause depression. Tests include CBC, TSH levels, and routine electrolyte, vitamin B12, and folate levels. Testing for illicit drug use is sometimes appropriate.