WebNov 27, 2022 · Valproate toxicity can occur both accidentally and intentionally. Toxicity can occur with dose adjustments to reach the therapeutic level, in patients with metabolic derangements, with drug-drug interactions, or in attempts to cause self-harm.
WebJul 10, 2023 · It is used to treat partial and generalized seizures and acute mania, and as prophylaxis for bipolar disorder and migraine headaches. Although acute VPA intoxication frequently results in mild, self-limited central nervous system depression, serious toxicity and death may occur.
WebOct 4, 2020 · At therapeutic levels, valproic acid is >80% bound to albumin. At toxic levels (e.g., >150 mcg/ml or >1,050 uM/L), protein binding is saturated and the fraction of free drug in the blood increases substantially. This may explain why neurologic symptoms start emerging around these levels.
WebAug 23, 2019 · Although most cases of valproate (valproic acid [VPA]) overdose are benign, serious toxicity, including death, may occur after acute ingestion. Signs and symptoms. Few historical...
WebAug 17, 2023 · Objectives: Evaluate the diverse mechanisms through which valproic acid exerts its therapeutic effects across various medical conditions. Analyze the evidence supporting the use of valproic acid in specific patient populations, such as pediatric patients, pregnant women, and older individuals.
WebOct 16, 2018 · Toxicity CNS depression is common, ranging from somnolence and lethargy to severe coma. 3, 4 Respiratory depression, hypotension, metabolic acidosis, and electrolyte abnormalities (such as hypocalcemia, hypernatremia, and hypophosphatemia) are possible. 3 Unique features of acute overdose include hepatitis, pancreatitis, …
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Thinking out of the box: management of valproic acid toxicity with
WebMar 10, 2021 · Abstract. Valproic acid (VPA) is commonly used medication to treat seizure disorder and as prophylaxis for bipolar disorder. Acute VPA toxicity can cause varied symptoms ranging from mild drowsiness to severe cerebral oedema and coma. The therapeutic level of VPA is around 50–100 µg/mL and most of it is protein bound.
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Valproic acid poisoning: An evidence-based consensus …
WebAlthough therapeutic doses of valproic acid can cause adverse effects in adults and children, some idiosyncratic and some dose-dependent, these cases are not considered. This guideline is based on an assessment of current scientific and clinical information.
WebValproic acid also alters fatty acid metabolism, with impairment of mitochondrial beta-oxidation and disruption of the urea cycle, and can cause hyperammonemia, hepatotoxicity, metabolic perturbations, pancreatitis, cerebral edema, and bone marrow depression.
WebDrugs & Medications. Valproic Acid Solution - Uses, Side Effects, and More. Generic Name (S): valproic acid (as sodium salt) Uses. This medication is used to treat seizure disorders,...